REQUIRED TESTS: GENOME, NUTREVAL
If you do not have a suitable genome analysis through a CLIA certified lab (23 and me and My Heritage DNA are acceptable direct to consumer labs) or recent metabolomic testing, please contact NGI. Genome kits can be purchased and de-identified through NGI for $150 and the Nutreval can be ordered through NGI as well for $379.
Methylation in its simplest terms is the moving around of methyl groups (little carbon/hydrogen complexes) in the cells. They are involved in gene expression, which means everything from turning on and off genes in normal cells to growing cancer. This also includes protein functions, which in the body basically means enzymes. Almost all chemical reactions in the body are dependent on enzymes to work, but they are very picky! They require the perfect temperature, cofactors like vitamins and minerals, and pH; if not, they don’t work and I say they are on “vacation”. Each of the following methylation SNPs requires specific cofactors and minerals to work, and some even come with dietary restrictions to correct the aberrant cycle. Some are even associated with disease conditions like Alzheimer’s, Autism Spectrum Disorders and cancer. When you have methylation cycle alterations, it predisposes you to a greater probability to age related degenerative diseases, neurotransmitter imbalances, allergies and the “mystery diseases” that seem to plague modern society. They compromise the body’s ability to detoxify not only external sources of stress, but the body’s own sources of waste, like ammonia. The good thing? All of these can be modulated and corrected – thus bringing the workers back from that extended holiday!
In this panel, we will review the results of several single nucleotide polymorphisms, SNPs, which can help us determine your risk or probability of developing certain conditions. Some conditions are more influenced by genetics, and some more by environmental conditions, like if you smoke, work in a new office building or drink out of plastic water bottles! Often times, these environmental conditions are the keys to controlling our genes. They are the risk modifiers. In this case, those modifications will be life altering, longevity modifiers, with the addition of nutritious foods and possibly very specific supplements. No other person on the planet has your exact genome. Therefore, no NutriGenomic plan is ever the same. This plan will be for you, based on your history, your conditions, your genes and your genes alone.
For the best results, it is strongly recommended that in addition to this written panel that you work with one of our Certified Nutrition Specialists (CNS) at the Nutritional Genomics Institute. Please contact NGI for scheduling.
What is Methylation?
DNA methylation is an epigenetic (on-top-of-the genome) mechanism for changing or controlling the expression pattern of your genes. The way it works is that methyl groups (small chemical groups) are added to the DNA strand. This has the effect of turning off sections of the genetic code without altering the DNA sequence. Why would you want to turn off a section of genetic code? There are actually many reasons. Some sections of the code are only needed for early development and pregnancy while other sections of code are only needed during time of great stress. Your methylation cycle is not only very important for gene expression but also plays a pivotal role in detoxification of external sources of stress and the body’s waste, like ammonia.
Why is Methylation Important?
Some genes involved in growth and proliferation for example if “ON” in the wrong context may lead to diseases like cancer. This occurs when there are not enough methyl groups around or when you are hypomethylated. However, just like hypomethylation (not enough methyl activity) can cause problems, hypermethylation (too much methyl activity) is also problematic because it leads to important genes that you need (EX: tumor suppressor genes) being turned off. The idea is to have the right balance of methylation; Not too much and not too little.
What information does this report contain?
This is a report of the SNPs (Single Nucleotide Polymorphisms) that you have in genes which code for proteins known to be important for methylation.
The MethylDx analyzes and explains the complexities of methylation and one carbon metabolism followed by detailed executions.
Metabolic testing is concurrently required for this analysis.(Nutreval)